反应详情

Prepared according to procedure B from 4′-bromo-2′-fluoroacetanilide and (1,4-dihydro-4,4-dimethyl-2-oxo-2H-3,1-benzoxazin-6-yl)boronic acid. Off white solid, mp 245-247° C. 1H-NMR (DMSO-d6) δ 10.3 (s, 1H), 9.79 (s, 1H), 7.95 (t, 1H, J=8.4 Hz), 7.56-7.63 (m, 3H), 7.47 (dd, 1H, J=1.64, 8.47 Hz), 6.95(d, 1H, J=8.9 Hz), 2.1 (s, 3H), 1.67 (s, 6H); MS+APCI [M+H]+m/z 329. Anal. Calc. For C18H17N2 FO3; C, 65.85; H, 5.22; N, 8.53. Found: C, 65.46; H, 5.24; N, 8.12.

1. customPrepared