HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 507522Generated: November 3, 2026
Potassium Carbonate → 1-(2-(4-(5-(Thiophen-2-yl)thiophen-2-yl)pyrimidin-2-ylamino)ethyl)-1H-benzo[d]imidazol-2(3H)-one
https://huagongshe.com/reaction/507522
Participants
| Role | Name | HCID | Charge |
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| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 1-(2-aminoethyl)-2,3-dihydro-1H-1,3-benzodiazol-2-one hydrochloride | HCID 18630889 | — |
| Reactant | 2-Chloro-4-(5-(thiophen-2-yl)thiophen-2-yl)pyrimidine | HCID 44613989 | — |
| Solvent | 1-Methylpyrrolidine | HCID 8454 | — |
| Product | 1-(2-(4-(5-(Thiophen-2-yl)thiophen-2-yl)pyrimidin-2-ylamino)ethyl)-1H-benzo[d]imidazol-2(3H)-one | HCID 60204269 | — |
Reaction Steps
A mixture of 2-chloro-4-(5-(thiophen-2-yl)thiophen-2-yl)pyrimidine (20 mg, 0.072 mmol), 1-(2-aminoethyl)-1H-benzo[d]imidazol-2(3H)-one hydrochloride salt (15 mg, 0.072 mmol) and potassium carbonate (20 mg, excess) in N-methylpyrrolidine (1 mL) was heated at 160° C. for 35 min in a Personal Chemistry microwave reactor. The solvent was removed in vacuo and the product was purified by HPLC to give the title compound (trifluoroacetate salt) as a yellow solid. MS (M+H)+ 420.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07786132B2 |
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| Source dataset | uspto-grants-2010_08 |
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| ORD ID | ord-2541c020249f4fd5b7d290d5bbdd8ff2 |
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| Source note | uspto-grants-2010_08 |
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