関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | N-(2-Aminoethyl)ethyleneurea | HCID 80480 | — |
| 反応物 | 4-(Benzo[b]thiophen-2-yl)-2-(methylsulfonyl)pyrimidine | HCID 57428827 | — |
| 溶媒 | 1-Methoxyethanol | HCID 3015637 | — |
| 生成物 | 1-(2-(4-(Benzo[b]thiophen-2-yl)pyrimidin-2-ylamino)ethyl)imidazolidin-2-one | HCID 60204306 | — |
反応手順
A mixture of 4-(benzo[b]thiophen-2-yl)-2-(methylsulfonyl)pyrimidine (75 mg, 0.26 mmol)), 1-(2-aminoethyl)imidazolidin-2-one (33 mg, 0.26 mmol) and triethylamine (32 mg, 0.31 mmol) in methoxyethanol (3 mL) was heated at 100° C. overnight. After cooling to rt the solvent was removed in vacuo and the product was purified by chromatography eluting with methanol/dichloromethane (1:20) to give the title compound as a slightly yellow solid (56 mg, 64%). MS (M+H)+ 340.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07786132B2 |
|---|
| 出典データセット | uspto-grants-2010_08 |
|---|
| ORD ID | ord-72932030c4064bb58a23803b89e4bfa8 |
|---|
| 出典メモ | uspto-grants-2010_08 |
|---|
