참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Sodium Carbonate | HCID 10340 | — |
| 반응물 | 1,4-Dioxane | HCID 31275 | — |
| 반응물 | 2,4-Dichloropyrimidine | HCID 77531 | — |
| 반응물 | 5-Cyanothiophene-2-boronic acid | HCID 4198743 | — |
| 촉매 | HCID 178418476 | HCID 178418476 | — |
| 용매 | Methanol | HCID 887 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 5-(2-Chloropyrimidin-4-yl)thiophene-2-carbonitrile | HCID 57428836 | — |
반응 단계
A solution of 0.22 g (1.4 mmol) of 5-cyanothiophen-2-ylboronic acid, 0.21 g (1.4 mmol) of 2,4-dichloropyrimidine and 49 mg (0.070 mmol) of bis(triphenylphosphine)palladium(II) chloride in 2 mL of a 2 M Na2CO3 aqueous solution and 5 mL of 1,4-dioxane was as heated in a microwave for 30 min at 140° C., then cooled to rt, diluted with CH2Cl2 and MeOH, and dried over MgSO4. The organic solvent was removed in vacuo, and the resulting solid was purified by flash chromatography eluting with a linear gradient of 50% EtOAc in hexane to neat EtOAc to deliver the title compound. MS (M+H)+ 222.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07786132B2 |
|---|
| 출처 데이터셋 | uspto-grants-2010_08 |
|---|
| ORD ID | ord-162f32b7cb2544d4b2a85e2fd1078312 |
|---|
| 출처 메모 | uspto-grants-2010_08 |
|---|
