3-Thiocresol → 5,5-Dimethyl-1-(2-{4-[5-(m-tolylthio)thiophen-2-yl]pyrimidin-2-ylamino}ethyl)imidazolidine-2,4-dione
Reaction equation
I[C:2]1[S:6][C:5]([C:7]2[CH:12]=[CH:11][N:10]=[C:9]([NH:13][CH2:14][CH2:15][N:16]3[C:20]([CH3:22])([CH3:21])[C:19](=[O:23])[NH:18][C:17]3=[O:24])[N:8]=2)=[CH:4][CH:3]=1.[CH3:25][C:26]1[CH:27]=[C:28]([SH:32])[CH:29]=[CH:30][CH:31]=1>>[CH3:21][C:20]1([CH3:22])[N:16]([CH2:15][CH2:14][NH:13][C:9]2[N:8]=[C:7]([C:5]3[S:6][C:2]([S:32][C:28]4[CH:27]=[C:26]([CH3:25])[CH:31]=[CH:30][CH:29]=4)=[CH:3][CH:4]=3)[CH:12]=[CH:11][N:10]=2)[C:17](=[O:24])[NH:18][C:19]1=[O:23]Participants
3
Procedure
The title compound was prepared from 1-{2-[4-(5-iodothiophen-2-yl)pyrimidin-2-ylamino]ethyl}-5,5-dimethyl-imidazolidine-2,4-dione and 3-methylthiophenol in a manner analogous to Example 259. MS (M+H)+ 454.
Sources & evidence
- ORD record
- ord-a6705f3f9d0547259efdda13a57ed4ca
- Source dataset
- uspto-grants-2010_08
- Patent number
- US07786132B2
Reaction notes
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