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HRID 507588作成日：2026年10月25日

3-(Methylcarbamoyl)benzeneboronic acid → 3-{4-(5-Chlorothiophen-2-yl)-2-[2-(5,5-dimethyl-2,4-dioxoimidazolidin-1-yl)ethylamino]pyrimidin-5-yl}-N-methylbenzamide

https://huagongshe.com/reaction/507588

反応式

関与物質

役割名称HCID仕込み量
反応物3-(Methylcarbamoyl)benzeneboronic acidHCID 2773524—
反応物1-{2-[5-Bromo-4-(5-chlorothiophen-2-yl)pyrimidin-2-ylamino]ethyl}-5,5-dimethylimidazolidine-2,4-dioneHCID 60204470—
生成物3-{4-(5-Chlorothiophen-2-yl)-2-[2-(5,5-dimethyl-2,4-dioxoimidazolidin-1-yl)ethylamino]pyrimidin-5-yl}-N-methylbenzamideHCID 60204488—

反応手順

The title compound was prepared from 1-{2-[5-bromo-4-(5-chlorothiophen-2-yl)pyrimidin-2-ylamino]ethyl}-5,5-dimethylimidazolidine-2,4-dione and 3-(methyl-carbamoyl)phenylboronic acid in a manner analogous to Example 269. MS (M+H)+ 499.

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US07786132B2
出典データセットuspto-grants-2010_08
ORD IDord-6409c2f0cca44f268c96058a9cd6086b
出典メモuspto-grants-2010_08