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6-(tetramethyl-1,3,2-dioxaborolan-2-yl)-2,3-dihydro-1H-indol-2-one → 1-{2-[4-(5-Chlorothiophen-2-yl)-5-(2-oxoindolin-6-yl)pyrimidin-2-ylamino]ethyl}-5,5-dimethylimidazolidine-2,4-dione
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 6-(tetramethyl-1,3,2-dioxaborolan-2-yl)-2,3-dihydro-1H-indol-2-one | HCID 46739162 | — |
| 反応物 | 1-{2-[5-Bromo-4-(5-chlorothiophen-2-yl)pyrimidin-2-ylamino]ethyl}-5,5-dimethylimidazolidine-2,4-dione | HCID 60204470 | — |
| 生成物 | 1-{2-[4-(5-Chlorothiophen-2-yl)-5-(2-oxoindolin-6-yl)pyrimidin-2-ylamino]ethyl}-5,5-dimethylimidazolidine-2,4-dione | HCID 60204492 | — |
反応手順
The title compound was prepared from 1-{2-[5-bromo-4-(5-chlorothiophen-2-yl)pyrimidin-2-ylamino]ethyl}-5,5-dimethylimidazolidine-2,4-dione and 6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)indolin-2-one in a manner analogous to Example 269. MS (M+H)+ 497.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07786132B2 |
| 出典データセット | uspto-grants-2010_08 |
| ORD ID | ord-4f63d50e7d4040a1a2441918d1bf091a |
| 出典メモ | uspto-grants-2010_08 |