2-Chloropyrimidine → 4-(5-Benzylthiophen-2-yl)-2-chloropyrimidine

HRID 507598Notes

Reaction equation

HRID 507598 reaction equation
[CH2:1]([C:8]1[S:9][CH:10]=[CH:11][CH:12]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[Cl:13][C:14]1[N:19]=[CH:18][CH:17]=[CH:16][N:15]=1>>[CH2:1]([C:8]1[S:9][C:10]([C:16]2[CH:17]=[CH:18][N:19]=[C:14]([Cl:13])[N:15]=2)=[CH:11][CH:12]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 744042-ChloropyrimidineHCID 139391Thiophene, 2-(phenylmethyl)-

Product 1

HCID 574288374-(5-Benzylthiophen-2-yl)-2-chloropyrimidine

Procedure

The title compound was prepared from 2-benzylthiophene and 2-chloropyrimidine in a manner analogous to Example 255, Step 1. MS (M+H)+ 287.

Sources & evidence

ORD record
ord-6cc45dbb2b074499bbb19da43e7e3345
Source dataset
uspto-grants-2010_08
Patent number
US07786132B2

Reaction notes

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