HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Bromothiazole → Thiazole, 2-(phenylthio)-
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Bromothiazole | HCID 76430 | — |
| Reactant | 1,1'-(9,9-Dimethyl-9H-xanthene-4,5-diyl)bis(1,1-diphenylphosphine) | HCID 636044 | — |
| Reactant | Sodium benzenethiolate | HCID 4110039 | — |
| Catalyst | Bis(dibenzylideneacetone)palladium | HCID 9811564 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | Thiazole, 2-(phenylthio)- | HCID 606073 | — |
Reaction Steps
A solution of sodium thiophenolate (0.61 g, 4.62 mmol) and 2-bromothiazole (0.38 mL, 4.2 mmol) in 20 mL of toluene was treated with 0.19 g (0.21 mmol) of Pd2dba3 and 0.12 g (0.21 mmol) of Xantphos and heated at reflux for 10 min. The crude solution was concentrated onto 5 g of silica gel and then purified by flash chromatography to give the title compound. MS (M+H)+ 194.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07786132B2 |
| Source dataset | uspto-grants-2010_08 |
| ORD ID | ord-f4267e351f8b497abbac57e4cfc78fa0 |
| Source note | uspto-grants-2010_08 |