Chloroform → HCID 60204503, compound

Participants

Reaction Steps

A solution of 150 mg (0.33 mmol) of 5-bromo-2-chloro-4-{2-[phenyl(trimethylsilyloxy)-methyl]-thiazol-5-yl}pyrimidine, 85 mg (0.50 mmol) of 1-(2-aminoethyl)-5,5-dimethylimidazolidine-2,4-dione and N,N-diisopropylethylamine (0.17 mL, 0.99 mmol) in 4 mL of iPrOH and 1 mol of CHCl3 was heated in a microwave to 170° C. for 20 min and then treated with 0.75 mL of a 1 M solution of tetra-n-butylammonium fluoride in THF for 10 min at rt. The reaction solution was concentrated in vacuo and the crude solid product was purified by flash chromatography eluting with a linear gradient of 75% EtOAc in hexane to 100% EtOAc to deliver the title compound. MS (M+H)+ 519.

Provenance & Evidence