HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 507616Generated: October 26, 2026
Cesium carbonate → HCID 60204516, compound
https://huagongshe.com/reaction/507616
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | 1,1'-(9,9-Dimethyl-9H-xanthene-4,5-diyl)bis(1,1-diphenylphosphine) | HCID 636044 | — |
| Reactant | Benzenesulfinic acid, sodium salt | HCID 2723840 | — |
| Reactant | 1-{2-[4-(5-Iodothiophen-2-yl)pyrimidin-2-ylamino]ethyl}-5,5-dimethylimidazolidine-2,4-dione | HCID 60204465 | — |
| Reactant | HCID 178418922 | HCID 178418922 | — |
| Catalyst | Benzyltributylammonium chloride | HCID 159952 | — |
| Catalyst | Bis(dibenzylideneacetone)palladium | HCID 9811564 | — |
| Solvent | Toluene | HCID 1140 | — |
| Solvent | tert-Butanol | HCID 6386 | — |
| Product | HCID 60204516 | HCID 60204516 | — |
Reaction Steps
A suspension of 50 mg (0.11 mmol) of 1-{2-[4-(5-iodothiophen-2-yl)pyrimidin-2-ylamino]ethyl}-5,5-dimethylimidazolidine-2,4-dione, 22 mg (0.13 mmol) of sodium benzenesulfinate, 3 mg (0.0027 mmol) of Pd2dba3, 3.5 mg (0.00547 mmol) of Xantphos, 71 mg (0.22 mmol) of cesium carbonate, 34 mg (0.109 mmol) of N-benzyl-tri-n-butylammonium chloride and 0.22 mL of a 1 M solution of tBuOK in tBuOH in 3 mL of toluene was heated to 110° C. in a microwave for 10 min. The toluene was removed in vacuo and the residue purified by C-8 prep HPLC to deliver the title compound. MS (M+H)+ 548.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07786132B2 |
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| Source dataset | uspto-grants-2010_08 |
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| ORD ID | ord-7d16da5214f6484db02467903c3c1f06 |
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| Source note | uspto-grants-2010_08 |
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