HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → 6-Fluoro-3-nitropyridine-2-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | Sulfuric Acid | HCID 1118 | — |
| Reactant | 2-Cyano-6-fluoro-3-nitropyridine | HCID 10844807 | — |
| Product | 6-Fluoro-3-nitropyridine-2-carboxamide | HCID 10535516 | 61% |
Reaction Steps
A solution of 2-cyano-6-fluoro-3-nitropyridine (1.40 g, 8.39 mmol) in 90% H2SO4 (30 mL) is warmed at 70° C. for 90 min, then cooled, poured onto ice and basified with conc. ammonia. Extraction with EtOAc and workup gives 6-fluoro-3-nitropyridine-2-carboxamide (0.94 g, 61%). 1H NMR (CDCl3) δ 8.70 (1H, dd, J=8.9, 6.5 Hz), 8.30, 8.03 (1H, 1H, brs), 7.62 (1H, dd, J=8.9, 2.9 Hz).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06713484B2 |
| Source dataset | uspto-grants-2004_03 |
| ORD ID | ord-9f0ab9496d0546c6aefe6eea3dcdb907 |
| Source note | uspto-grants-2004_03 |