Water → 5-Methyl-2-(methylsulfonyl)-4-(thiophen-2-yl)pyrimidine

HRID 507650Notes

Reaction equation

HRID 507650 reaction equation
[CH3:1][C:2]1[C:3]([C:10]2[S:11][CH:12]=[CH:13][CH:14]=2)=[N:4][C:5]([S:8][CH3:9])=[N:6][CH:7]=1.[OH2:15].[OH:16]OS([O-])=O.[K+]>CC(C)=O>[CH3:1][C:2]1[C:3]([C:10]2[S:11][CH:12]=[CH:13][CH:14]=2)=[N:4][C:5]([S:8]([CH3:9])(=[O:16])=[O:15])=[N:6][CH:7]=1

Participants

5

Reactant 3

HCID 962WaterHCID 23707502Potassium hydroxy sulfiteHCID 574288625-Methyl-2-(methylthio)-4-(thiophen-2-yl)pyrimidine

Product 1

HCID 574288635-Methyl-2-(methylsulfonyl)-4-(thiophen-2-yl)pyrimidine

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

5-Methyl-2-(methylthio)-4-(thiophen-2-yl)pyrimidine (0.15 g, 0.67 mmol) was dissolved in acetone (10 mL) and then water (10 mL) was added. Oxone (1.2 g, 2.02 mmol) was added in small portions to the reaction mixture, which was allowed to stir overnight at ambient temperature. The white precipitate that formed during the course of the reaction was collected by suction filtration and washed several times with water and then dried in a vacuum oven at 60° C. Yield=0.12 g. MS (M+H)+ 255.

Workup

  1. customThe white precipitate that formed during the course of the reaction
  2. filtrationwas collected by suction filtration
  3. washwashed several times with water
  4. customdried in a vacuum oven at 60° C

Sources & evidence

ORD record
ord-83671d589c86470b835724599ee75f41
Source dataset
uspto-grants-2010_08
Patent number
US07786132B2

Reaction notes

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