Acetone → HCID 60204556, compound

HRID 507653Notes

Reaction equation

HRID 507653 reaction equation
[Br:1][C:2]1[S:6][C:5]([C:7]2[C:12]([CH3:13])=[CH:11][N:10]=[C:9](SC)[N:8]=2)=[CH:4][CH:3]=1.O[O:17][S:18]([O-:20])=O.[K+].[CH3:22]C(C)=O>O>[Br:1][C:2]1[S:6][C:5]([C:7]2[C:12]([CH3:13])=[CH:11][N:10]=[C:9]([S:18]([CH3:22])(=[O:20])=[O:17])[N:8]=2)=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 180AcetoneHCID 23707502Potassium hydroxy sulfiteHCID 57428864HCID 57428864, compound

Product 1

HCID 60204556HCID 60204556, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

4-(5-Bromothiophen-2-yl)-5-methyl-2-(methylthio)pyrimidine (2.5 g, 3.3 mmol) dissolved in acetone (50 mL) was treated, via slow addition, with a solution of oxone (15.3 g, 24 mmol) in water (50 mL). The reaction was allowed to stir overnight at ambient temperature. The white precipitate that formed during the course of the reaction was collected by filtration and washed several times with water and then dried in a vacuum oven at 60° C. Yield=2.3 g. MS (M+H)+ 334.

Workup

  1. customThe white precipitate that formed during the course of the reaction
  2. filtrationwas collected by filtration
  3. washwashed several times with water
  4. customdried in a vacuum oven at 60° C

Sources & evidence

ORD record
ord-5d7071ea5fd0412983bf23214da3d9e8
Source dataset
uspto-grants-2010_08
Patent number
US07786132B2

Reaction notes

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