Hydrochloric Acid → HCID 178517754, compound

Participants

Reaction Conditions

Reaction Steps

4-(Benzo[b]thiophen-2-yl)-2-(methylthio)-5-(trifluoromethyl)pyrimidine (0.45 g, 1.3 mmol) suspended in dioxane (3 mL) was treated with 5 N sodium hydroxide (3 mL) and the reaction heated to 75° C. After stirring overnight, there was still some starting material present in the reaction mixture by LC-MS. An additional 3 mL of 5 N sodium hydroxide was added to the reaction mixture and the temperature was increased to 90° C. After 6 h, the reaction was cooled to room temperature and acidified to pH 4 with 1 N hydrochloric acid. The precipitate that formed was collected by suction filtration, washed well with water and dried in a vacuum oven to give a white solid. Yield=0.31 g. MS (M+H)+ 297.

Provenance & Evidence