反应详情

Methyl 7-chlorobenzo[b]thiophene-2-carboxylate (3 g, 13 mmol) was dissolved is ethanol (15 mL) and treated 5 N sodium hydroxide (5 mL). The reaction was heated at reflux overnight. The volatiles were removed in vacuo and the aqueous residue was acidified to pH 2 using 5 N HCl. The resulting white solid was filtered off, washed well with water and dried in a vacuum oven at 60° C. Yield=2.6 g. MS (M−H)− 210.

1. temperatureThe reaction was heated
2. temperatureat reflux overnight
3. customThe volatiles were removed in vacuo
4. filtrationThe resulting white solid was filtered off
5. washwashed well with water
6. customdried in a vacuum oven at 60° C