17-Azido-3,6,9,12,15-pentaoxaheptadecan-1-amine → HCID 66933864, compound

HRID 507744Notes

Reaction equation

HRID 507744 reaction equation
NCCOCCOCC[O:10][CH2:11][CH2:12][NH:13][C:14]([CH2:16][CH2:17][C@H:18]([NH:26][C:27]([C:29]1[CH:34]=[CH:33][C:32]([N:35](C(OCC2C=CC=CC=2)=O)[CH3:36])=[CH:31][CH:30]=1)=[O:28])[C:19]([O:21][C:22]([CH3:25])([CH3:24])[CH3:23])=[O:20])=[O:15].NCCO[CH2:51][CH2:52][O:53][CH2:54][CH2:55][O:56][CH2:57][CH2:58][O:59][CH2:60][CH2:61][O:62][CH2:63][CH2:64][N:65]=[N+]=[N-]>>[NH2:65][CH2:64][CH2:63][O:62][CH2:61][CH2:60][O:59][CH2:58][CH2:57][O:56][CH2:55][CH2:54][O:53][CH2:52][CH2:51][O:10][CH2:11][CH2:12][NH:13][C:14]([CH2:16][CH2:17][C@H:18]([NH:26][C:27]([C:29]1[CH:34]=[CH:33][C:32]([NH:35][CH3:36])=[CH:31][CH:30]=1)=[O:28])[C:19]([O:21][C:22]([CH3:25])([CH3:24])[CH3:23])=[O:20])=[O:15]

Participants

3

Reactant 2

HCID 2189447617-Azido-3,6,9,12,15-pentaoxaheptadecan-1-amineHCID 66910315HCID 66910315, compound

Product 1

HCID 66933864HCID 66933864, compound

Procedure

Compound 26 (linker moiety where n=5) was synthesized by an analogous procedure as employed for compound 12, but using 1-amino-17-azido-3,6,9,12,15-pentaoxaheptadecane instead of 1-amino-11-azido-3,6,9-trioxaundecane in the first step of synthesis.

Workup

  1. customin the first step of synthesis

Sources & evidence

ORD record
ord-30e9af3e6827445aa132fc35a440bb77
Source dataset
uspto-grants-2010_08
Patent number
US07786112B2

Reaction notes

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