Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Diethyl Ether | HCID 3283 | — |
| Reactant | Dichloromethane methanol | HCID 21226129 | — |
| Reactant | tert-butyl (2S)-2-{[4-(methylamino)phenyl]carbonylamino}-4-{N-[2-(2-{2-[2-(2-{2-[2-(4-{5-[(N-morpholin-4-ylcarbamoyl)amino]-4-oxoindeno[3,2-c]pyrazol-3-yl}phenoxy)acetylamino]ethoxy}ethoxy)ethoxy]ethoxy}ethoxy)ethyl]carbamoyl}butanoa te | HCID 178482177 | — |
| Reactant | HCID 178482983 | HCID 178482983 | — |
| Solvent | Dimethylacetamide | HCID 31374 | — |
| Product | Ammonium Hydroxide | HCID 14923 | 1% |
| Product | HCID 178482983 | HCID 178482983 | 60% |
Reaction Steps
Compound 28 (0.65 g, 0.62 mmol) was dissolved in dimethylacetamide and 0.4 g of compound 14 (1.2 mmol) was added to the reaction mixture as a solid. The reaction mixture was heated to 60° C. for 6 hours, then let cool to room temperature and 80 ml diethyl ether added and let stand for 3 days. The supernatant was decanted off leaving a dark brown residue, which was purified by flash silica chromatography (5 to 10% MeOH/CH2Cl2 then 5 to 10% MeOH/CH2Cl2 W/1% NH4OH) to give 0.45 g (0.37 mmol, 60%) of a yellow solid (compound 30).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07786112B2 |
|---|
| Source dataset | uspto-grants-2010_08 |
|---|
| ORD ID | ord-e400b7365ab64496be7d9a3d143a8c90 |
|---|
| Source note | uspto-grants-2010_08 |
|---|
