Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-Methylpiperazine-1-carbonyl chloride monohydrochloride → Zopiclone
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-Methylpiperazine-1-carbonyl chloride monohydrochloride | HCID 3016934 | — |
| 반응물 | 6-(5-Chloro-2-pyridyl)-6,7-dihydro-7-hydroxy-5H-pyrrolo(3,4-b)pyrazin-5-one | HCID 6451972 | — |
| 용매 | Triethylamine | HCID 8471 | — |
| 생성물 | Zopiclone | HCID 5735 | — |
반응 단계
reacting 6-(5-chloropyrid-2-yl)-5-hydroxy-7-oxo-5,6-dihydropyrrolo[3,4-b]pyrazine with 1-chlorocarbonyl-4-methylpiperazine hydrochloride in an organic solvent in presence of triethyl amine along with a catalytic amount of an acylation catalyst to obtain racemic zopiclone;
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07786304B2 |
| 출처 데이터셋 | uspto-grants-2010_08 |
| ORD ID | ord-5e07df90252647c8bf03cbfce42e4c2c |
| 출처 메모 | uspto-grants-2010_08 |