化工社化工社 化学情報印刷レポート · 研究参考用
2-Amino-5-chloropyridine → 3-(5-Chloropyrid-2-yl)carbamoylpyrazine-2-carboxylic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Amino-5-chloropyridine | HCID 66174 | — |
| 反応物 | Furo(3,4-b)pyrazine-5,7-dione | HCID 78482 | — |
| 生成物 | 3-(5-Chloropyrid-2-yl)carbamoylpyrazine-2-carboxylic acid | HCID 3280818 | 85% |
反応手順
The addition of 2-amino-5-chloropyridine to pyrazine 2,3-dicarboxylic acid anhydride (II) in a lot wise manner at room temperature in a molar ratio of 1.05:1 surprisingly accelerates the reaction to completion in resulting the product, 3-(5-chloropyrid-2-yl)carbamoyl-pyrazine-2-carboxylic acid (III) having high purity (>99%) with a good yield of 85 to 90% when compared with the prior art processes.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07786304B2 |
| 出典データセット | uspto-grants-2010_08 |
| ORD ID | ord-f02e56f6fbad4c4a87ecdbf8dca27859 |
| 出典メモ | uspto-grants-2010_08 |