Hydrochloric Acid → HCID 68624795, compound

Participants

Reaction Steps

The solution of 0.030 g of tert-butyl (1(S)-{1(S)-hydroxy-2-[2-methyl-2-(tetrahydropyran-4-yl)-propionylamino]ethyl}-3(S)-{[2-(3-methoxypropoxy)benzoylamino]methyl}-4-methylpentyl)-carbamate in 1 ml of 4M HCl (in dioxane) is stirred at 0° C. to 20° C. over 2 hours and subsequently concentrated by evaporation to dryness, and the residue is dissolved in 1 ml of tert-butanol, frozen and lyophilized under high vacuum. The title compound is obtained as a white powder. Rf=0.23 (200:20:1 dichloromethane-methanol-25% conc. ammonia); Rt=3.46 (gradient I).

Provenance & Evidence