Triethylamine → HCID 68622419, compound

Participants

Reaction Steps

0.007 ml of propane-2-sulphonyl chloride is added at 0° C. to a solution of 0.0255 g of tert-butyl (1(S)-(2-amino-1(S)-hydroxyethyl)-3(S)-{[2-(3-methoxypropoxy)benzoylamino]methyl}-4-methylpentyl)carbamate (Example 2b) and 0.007 ml of triethylamine in 1 ml of dichloromethane. After 6 hours, the reaction mixture is concentrated by evaporation—the N-Boc intermediate is identified from the residue by means of flash chromatography (SiO2 60F) on the basis of the Rf value. This is dissolved in 0.82 ml of 4N HCl/dioxane—after 4 hours, the reaction mixture is concentrated by evaporation, and the residue is dissolved in 0.5 ml of tert-butanol, frozen in liquid nitrogen and lyophilized under high vacuum overnight. The title compound is identified from the residue on the basis of the Rf value.

Provenance & Evidence