Methanesulfonyl chloride → HCID 59434281, compound

Participants

Reaction Conditions

Reaction Steps

3-[4-(4-fluoro-phenylamino)-piperidin-1-yl]-8-aza-bicyclo[3.2.1]octane-8-carboxylic acid ethyl ester (25 mg; 0.07 mmol; 1 eq.) was dissolved in dry prydine (2 mL) and MsCl (19 mg; 2.5 eq.) was added. The reaction mixture was heated to 80° C. and stirred under N2 overnight. The solution was diluted with DCM (10 mL) and washed with saturated NaHCO3 (2×20 mL). The organic layer was dried over Na2SO4, filtered, and concentrated under high vacuum to provide the product as an oil. The crude residue was purified by reversed-phase HPLC (2-99% CH3CN/water gradient with 0.05% TFA). LC/MS M/Z 454.2, Retention time=1.88 minutes; 10-99% CH3CN/H2O gradient with 0.05% TFA.

Provenance & Evidence