Hydrochloric Acid → 2-(3-Chlorophenoxy)-N-(4-dimethylamino-4-phenylcyclohexyl)acetamide hydrochloride

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Reaction Steps

As described for Example 235, 356 mg of the less polar diastereoisomer of 2-(3-chlorophenoxy)-N-(4-dimethylamino-4-phenylcyclohexyl)acetamide were also obtained and, as a solution in 5 ml 2-butanone and 10 ml ethyl acetate, were converted into the corresponding hydrochloride by addition of 17 μl water and 117 μl chlorotrimethylsilane (338 mg of a white solid, m.p. 223-224.5° C.).

Provenance & Evidence