HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → N-(4-Dimethylamino-4-phenylcyclohexyl)-4-phenoxybutyramide hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Water | HCID 962 | — |
| Reactant | Chlorotrimethylsilane | HCID 6397 | — |
| Reactant | N-(4-dimethylamino-4-phenylcyclohexyl)-4-phenoxybutyramide | HCID 11546187 | — |
| Solvent | Methyl Ethyl Ketone | HCID 6569 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | N-(4-Dimethylamino-4-phenylcyclohexyl)-4-phenoxybutyramide hydrochloride | HCID 11546186 | — |
Reaction Steps
As described for Example 237, 575 mg of the less polar diastereoisomer of N-(4-dimethylamino-4-phenylcyclohexyl)-4-phenoxybutyramide were also obtained and, as a solution in 5 ml 2-butanone and 5 ml ethyl acetate, were converted into the corresponding hydrochloride by addition of 27.2 μl water and 190 μl chlorotrimethylsilane (530 mg of a white solid, m.p. 194-197° C.).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07786328B2 |
| Source dataset | uspto-grants-2010_08 |
| ORD ID | ord-70e615d71e504a42a9ea129c3a638a2f |
| Source note | uspto-grants-2010_08 |