(4-{[(2-Phenylethyl)(4-phenyl-1,3-thiazol-2-yl)amino]methyl}phenyl)methanol → 4-{[(2-Phenylethyl)(4-phenyl-1,3-thiazol-2-yl)amino]methyl}benzaldehyde

Participants

Reaction Steps

To a solution of (4-{[(2-phenylethyl)(4-phenyl-1,3-thiazol-2-yl)amino]methyl}phenyl)methanol (3.0 g, 7.49 mmol) in tetrahydrofuran (50 mL) was added manganese dioxide (1.95 g, 22.5 mmol), and the mixture was stirred at room temperature for 3 hr. The insoluble material was filtered off and the filtrate was concentrated. The residue was purified by silica gel column chromatography (5%-50% ethyl acetate/hexane) to give the title compound (2.02 g, yield 68%) as a colorless oil.

Provenance & Evidence