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To a mixture of 4-isobutoxy-3-{[(2-phenylethyl)(4-phenyl-1,3-thiazol-2-yl)amino]methyl}benzaldehyde (1.43 g, 3.04 mmol), methanol (5 mL) and tetrahydrofuran (10 mL) was added sodium borohydride (58 mg, 1.52 mmol) under stirring at 0° C., and the mixture was stirred at the same temperature for 2 hr. The reaction mixture was diluted with ethyl acetate, washed with water and saturated brine, dried, and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (hexane/ethyl acetate=10/1-1/1) to give the title compound (1.28 g, yield 88%) as colorless crystals.

1. stirringthe mixture was stirred at the same temperature for 2 hr
2. washwashed with water and saturated brine
3. customdried
4. concentrationconcentrated under reduced pressure
5. customThe residue was purified by silica gel column chromatography (hexane/ethyl acetate=10/1-1/1)