Hydrochloric Acid → HCID 23157318, compound

Participants

Reaction Steps

A mixture of N-[4-(chloromethyl)-2-oxo-2H-chromen-7-yl]-2-nitrobenzenesulfonamide (14.3 g, 36.2 mmol) and 1 M aqueous sodium hydroxide solution (120 mL) was stirred at room temperature for 24 hr. The reaction mixture was acidified with 1 M hydrochloric acid, and the mixture was extracted with a mixed solvent of ethyl acetate and tetrahydrofuran. The extract was washed with saturated brine, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure to give the title compound (13.6 g, quant.) as pale-brown crystals.

Provenance & Evidence