反应详情

To a mixture of ethyl 3-tert-butyl-1H-pyrazole-5-carboxylate (4.00 g, 20.4 mmol) and tetrahydrofuran (50 mL) was added lithium aluminum hydride (800 mg, 21.1 mmol) by small portions under ice-cooling, and the mixture was stirred at the same temperature for 1 hr. Sodium sulfate decahydrate (7.6 g) was added to the reaction mixture, and the insoluble material was filtered off. The filtrate was concentrated and a mixture of the obtained residue, manganese dioxide (10 g, 115 mmol) and tetrahydrofuran (100 mL) was stirred at room temperature for 3 hr. The insoluble material was filtered off, and the filtrate was concentrated to give the title compound (2.13 g, yield 69%) as colorless crystals.

1. temperaturecooling
2. filtrationthe insoluble material was filtered off
3. concentrationThe filtrate was concentrated
4. stirringwas stirred at room temperature for 3 hr
5. filtrationThe insoluble material was filtered off
6. concentrationthe filtrate was concentrated