Dimethylformamide → HCID 23157487, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 4-hydroxyindan-1-one (2.94 g, 19.8 mmol), 2-chloro-5-(trifluoromethyl)pyridine (3.00 g, 16.5 mmol), potassium-carbonate (6.84 g, 49.5 mmol) and N,N-dimethylformamide (40 mL) was stirred under a nitrogen atmosphere at 100° C. for 8 hr. After cooling, the reaction mixture was diluted with ethyl acetate, washed with water, dried, and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (hexane/ethyl acetate=95/5-hexane/ethyl acetate=60/40) to give the title compound (2.74 g, yield 69%) as pale-yellow crystals.

Provenance & Evidence