反应详情

A mixture of methyl 4′-(benzyloxy)-2′,6,6′-trimethylbiphenyl-3-carboxylate (255 mg, 0.71 mmol), 10% palladium-carbon (50% water-containing product, 25.5 mg) and ethanol (3 mL) was stirred overnight under a hydrogen atmosphere at room temperature. The catalyst was filtered off, and the filtrate was concentrated under reduced pressure. The residue was again subjected to the above-mentioned conditions (10% palladium-carbon (50% water-containing product, 127 mg), stirring time 2 hr) to give the title compound (199 mg, yield 100%) as a colorless oil.

1. filtrationThe catalyst was filtered off
2. concentrationthe filtrate was concentrated under reduced pressure
3. stirringThe residue was again subjected to the above-mentioned conditions (10% palladium-carbon (50% water-containing product, 127 mg), stirring time 2 hr)