Hydrogen chloride-ethyl acetate → 3-[4-({[4'-(2-Ethoxyethoxy)-2',6'-dimethylbiphenyl-3-yl]methyl}amino)-2-fluorophenyl]propanoic acid hydrochloride

Participants

Reaction Steps

To a solution of 3-[4-({[4′-(2-ethoxyethoxy)-2′,6′-dimethylbiphenyl-3-yl]methyl}amino)-2-fluorophenyl]propanoic acid (2.66 g, 5.72 mmol) in ethyl acetate (15 mL) was added 4 N hydrogen chloride/ethyl acetate solution (5 mL), and the resulting solid was pulverized and washed with ethyl acetate-diethyl ether to give the title compound as colorless crystals (2.78 g, yield 97%).

Provenance & Evidence