Methanesulfonic Acid → 3-(2-fluoro-4-{[4-({5-(2-phenylethyl)-3-[4-(trifluoromethyl)phenyl]-1H-pyrazol-1-yl}methyl)benzyl]amino}phenyl)propanoic acid methanesulfonate

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Reaction Steps

To a solution of 3-(2-fluoro-4-{[4-({5-(2-phenylethyl)-3-[4-(trifluoromethyl)phenyl]-1H-pyrazol-1-yl}methyl)benzyl]amino}phenyl)propanoic acid (500 mg, 0.83 mmol) in ethyl acetate (20 mL) was added methanesulfonic acid (95 mg, 1.0 mmol) at room temperature, and the mixture was stirred for 1 hr. The reaction mixture was concentrated, isopropyl ether was added and the precipitated crystals were collected by filtration, washed with isopropyl ether and dried to give the title compound as colorless crystals (348 mg, yield 60%).

Provenance & Evidence