Thioglycolic Acid → HCID 23157602, compound

Participants

Reaction Steps

To a solution of tert-butyl 3-(4-{({4′-[2-(ethylsulfonyl)ethoxy]-2′,6′-dimethylbiphenyl-3-yl}methyl)[(2-nitrophenyl)sulfonyl]amino}-2-fluorophenyl)propanoate (1.67 g, 2.21 mmol) and mercaptoacetic acid (0.51 mL, 6.64 mmol) in N,N-dimethylformamide (17 mL) was added lithium hydroxide monohydrate (0.56 g, 13.3 mmol) under stirring at room temperature, and the mixture was stirred at the same temperature for 2 hr. The reaction mixture was diluted with ethyl acetate, washed with saturated aqueous sodium hydrogencarbonate. and saturated brine, dried, and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (hexane/ethyl acetate=4/1-hexane/ethyl acetate=1/1) to give the title compound (1.17 g, yield 93%) as a colorless oil.

Provenance & Evidence