Hydrochloric Acid → HCID 86624380, compound

Participants

Reaction Steps

To a mixture of ethyl 3-{4-[({2′,6′-dimethyl-4′-[3-(2-oxopyrrolidin-1-yl)propoxy]biphenyl-3-yl}methyl)amino]-2-fluorophenyl}propanoate (1.13 g, 2.07 mmol), methanol (5 mL) and tetrahydrofuran (10 mL) was added 1 M aqueous sodium hydroxide solution (4.14 mL), and the mixture was stirred at room temperature for 2 hr. The reaction mixture was neutralized with 1M hydrochloric acid, and diluted with ethyl acetate, and the organic layer was washed with saturated brine, dried, and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (hexane/ethyl acetate=4/1-hexane/ethyl acetate=1/2) to give a colorless oil. The obtained oil was diluted with ethyl acetate, and benzenesulfonic acid was added. The precipitated crystals were collected by filtration, washed, and dried to give the title compound (0.78 g, yield 56%) as colorless crystals.

Provenance & Evidence