Acetic Acid → HCID 23157418, compound

Participants

Reaction Steps

To a solution of 3-[(3,5-di-tert-butyl-1H-pyrazol-1-yl)methyl]-4-isobutoxybenzaldehyde (0.43 g, 1.16 mmol) and ethyl 3-(4-amino-2-fluorophenyl)propanoate (0.25 g, 1.16 mmol) in 1,2-dichloroethane (8.6 mL) was added acetic acid (0.20 mL, 3.48 mmol), and the mixture was stirred at room temperature for 3 hr. Sodium triacetoxyborohydride (0.74 g, 3.48 mmol) was added, and the mixture was further stirred for 5 hr. The reaction mixture was diluted with ethyl acetate, washed with saturated aqueous sodium hydrogencarbonate and saturated brine, dried, and concentrated under reduced pressure to give the title compound (0.62 g, yield 100%) as a colorless oil.

Provenance & Evidence