Hydrochloric Acid → HCID 23157637, compound

Participants

Reaction Steps

To a mixture of ethyl 3-[4-({3-[(3,5-di-tert-butyl-1H-pyrazol-1-yl)methyl]-4-isobutoxybenzyl}amino)-2-fluorophenyl]propanoate (0.62 g, 1.16 mmol), methanol (6 mL) and tetrahydrofuran (12 mL) was added 1 M aqueous sodium hydroxide solution (2.32 mL), and the mixture was stirred at room temperature for 2 hr. The reaction mixture was neutralized with 1M hydrochloric acid, and diluted with ethyl acetate, and the organic layer was washed with saturated brine, dried, and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (hexane/ethyl acetate=4/1-hexane/ethyl acetate=1/4) to give the title compound (0.52 g, yield 83%) as colorless crystals.

Provenance & Evidence