Hydrochloric Acid → HCID 68717522, compound

Participants

Reaction Steps

To a solution of 3-(4-{(4-{4-[2-(ethylsulfonyl)ethoxy]-2,6-dimethylphenyl}-2,3-dihydro-1H-inden-1-yl)[(2-nitrophenyl)sulfonyl]amino}-2-fluorophenyl)propanoic acid (0.620 g, 0.856 mmol) and mercaptoacetic acid (0.181 mg, 1.97 mmol) in N,N-dimethylformamide (20 mL) was added lithium hydroxide monohydrate (0.143 g, 3.42 mmol), and the mixture was stirred at room temperature for 2.5 hr. The reaction mixture was diluted with water, neutralized with 1 N hydrochloric acid and extracted with ethyl acetate. The extract was washed with saturated brine, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (hexane-25% ethyl acetate/hexane), and the obtained residue was dissolved in ethyl acetate (10 mL) and treated with 4 N hydrogen chloride/ethyl acetate solution (0.170 mL) to give the title compound as colorless crystals (0.127 g, yield 26%).

Provenance & Evidence