Trifluoroacetic acid → HCID 59434151, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of tert-butyl 3-{4-[({4′-[(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)methoxy]-2′,6′-dimethylbiphenyl-3-yl}methyl)amino]-2-fluorophenyl}propanoate (0.08 g, 0.14 mmol) in methylene chloride (2 mL) was added trifluoroacetic acid (2 mL) under stirring at 0° C., and the mixture was stirred at room temperature for 2 hr. The reaction mixture was concentrated under reduced pressure, and the residue was neutralized with saturated aqueous sodium hydrogencarbonate, and the mixture was extracted with ethyl acetate. The organic layer was washed with saturated brine, dried over anhydrous sodium sulfate, and concentrated under reduced pressure. The residue was recrystallized from ethyl acetate-hexane to give the title compound (0.06 g, yield 78%) as colorless crystals.

Provenance & Evidence