HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 508159Generated: October 29, 2026
Thionyl Chloride → 4-(Chloromethyl)-2-(4-chloro-3-methylphenyl)-1,3-oxazole
https://huagongshe.com/reaction/508159
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | [2-(4-Chloro-3-methylphenyl)-1,3-oxazol-4-yl]methanol | HCID 58284347 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 4-(Chloromethyl)-2-(4-chloro-3-methylphenyl)-1,3-oxazole | HCID 44541971 | — |
Reaction Steps
136 mg (0.61 mmol) of the compound from Example 27A are suspended in 2 ml of dichloromethane. The suspension is cooled to 0° C., and 49 μl (0.67 mmol) of thionyl chloride are added slowly. The reaction solution is stirred at RT overnight. The solvent is then removed on a rotary evaporator. The residue is used without further purification in the subsequent reactions.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09095582B2 |
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| Source dataset | uspto-grants-2015_08 |
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| ORD ID | ord-11fa7d888c304aceb6bce33ccfc5a02c |
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| Source note | uspto-grants-2015_08 |
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