反应详情

温度

65 °C

A mixture of 4-bromo-2,5-difluorobenzoic acid (i-7b) (0.48 g, 2 mmol) and methanol (10 mL, saturated with gaseous HCl) was heated at 65° C. for 2 h. The mixture was concentrated. Then MeOH was added and the mixture was concentrated again. The residue was purified by flash chromatography (Pentane/EtOAc=4:1) to give the title compound. LCMS (ESI) calc'd for C8H5BrF2O2 [M+H]+: 251. found: 251.

1. concentrationThe mixture was concentrated
2. additionThen MeOH was added
3. concentrationthe mixture was concentrated again
4. customThe residue was purified by flash chromatography (Pentane/EtOAc=4:1)