HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Bromoaniline → N-(3-bromophenyl)-6-fluoropyrido[3,4-d]pyrimidin-4-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Bromoaniline | HCID 11562 | — |
| Reactant | Phosphorus oxychloride | HCID 24813 | — |
| Reactant | 6-fluoropyrido[3,4-d]pyrimidin-4-ol | HCID 135417370 | — |
| Product | N-(3-bromophenyl)-6-fluoropyrido[3,4-d]pyrimidin-4-amine | HCID 5328260 | 63% |
Reaction Steps
Reaction of 6-fluoro-3H-pyrido[3,4-d]pyrimidin-4-one (0.60 g, 3.6 mmol) with POCl3, followed by reaction of the crude 4,6-dihalo compound with 3-bromoaniline gives 4-(3-bromoanilino)-6-fluoropyrido[3,4-d]pyrimidine (0.73 g, 63%). 1H NMR (DMSO) δ 10.09 (1H, brs), 8.96 (1H, s), 8.75 (1H, s), 8.25 (2H, m), 7.90 (1H, brd, J=6.5 Hz), 7.44-7.34 (2H, m).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06713484B2 |
| Source dataset | uspto-grants-2004_03 |
| ORD ID | ord-7aea978a09a74dfcacd6e08e72c87656 |
| Source note | uspto-grants-2004_03 |