HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylamine → 4-N-(3-bromophenyl)-6-N,6-N-dimethylpyrido[3,4-d]pyrimidine-4,6-diamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylamine | HCID 674 | — |
| Reactant | N-(3-bromophenyl)-6-fluoropyrido[3,4-d]pyrimidin-4-amine | HCID 5328260 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 4-N-(3-bromophenyl)-6-N,6-N-dimethylpyrido[3,4-d]pyrimidine-4,6-diamine | HCID 5328261 | — |
Reaction Steps
Treatment of 4-(3-bromoanilino)-6-fluoropyrido[3,4-d]pyrimidine (see a previous experimental) at 100° C. in a pressure vessel with dimethylamine in ethanol gives 4-(3-bromoanilino)-6-dimethylaminopyrido[3,4-d]pyrimidine. 1H NMR (DMSO) δ 9.71 (1H, s), 8.83 (1H, s), 8.43 (1H, s), 8.21 (1H, brs), 7.94 (1H, brd, J=7.5 Hz), 7.42-7.29 (2H, m), 7.26 (1H, s), 3.17 (6H, s).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06713484B2 |
| Source dataset | uspto-grants-2004_03 |
| ORD ID | ord-f720d7c72cd64dd39366d97e1285f937 |
| Source note | uspto-grants-2004_03 |