Ammonia → 4-N-(3-bromophenyl)pyrido[2,3-d]pyrimidine-4,7-diamine

Participants

Role	Name	HCID	Charge
Reactant	Ammonia	HCID 222	—
Reactant	N-(3-bromophenyl)-7-fluoropyrido[2,3-d]pyrimidin-4-amine	HCID 5328268	—
Solvent	Ethanol	HCID 702	—
Product	4-N-(3-bromophenyl)pyrido[2,3-d]pyrimidine-4,7-diamine	HCID 5328267	90%

Reaction Conditions

Temperature	100 °C

Reaction Steps

A solution of 4-(3-bromoanilino)-7-fluoropyrido[2,3-d]pyrimidine (0.20 g, 0.63 mmol) in EtOH (20 mL) is saturated with ammonia and warmed at 100° C. in a pressure vessel for 30 h. The solvent is removed under reduced pressure to give 7-amino-4-(3-bromoanilino)pyrido[2,3-d]pyrimidine (0.18 g, 90%). 1H NMR (DMSO) δ 9.97 (1H, brs), 8.59 (1H, s), 8.51 (1H, d, J=9.3 Hz), 8.11 (1H, sl brs), 7.77 (1H, brd, J=6.3 Hz), 7.44 (2H, brs), 7.37-7.30 (2H, m), 6.81 (1H, d, J=9.3 Hz).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US06713484B2
Source dataset	uspto-grants-2004_03
ORD ID	ord-a93115e1909d40c3965843845a5a529f
Source note	uspto-grants-2004_03