Thionyl Chloride → HCID 86652125, compound

HRID 508370Notes

Reaction equation

HRID 508370 reaction equation
[C:1]([C:5]1[C:6]([O:35][CH3:36])=[C:7]([CH:24]=[C:25]([N:27]2[CH:32]=[CH:31][C:30](=[O:33])[NH:29][C:28]2=[O:34])[CH:26]=1)/[CH:8]=[CH:9]/[C:10]1[CH:18]=[CH:17][C:16]([NH:19][S:20]([CH3:23])(=[O:22])=[O:21])=[CH:15][C:11]=1[C:12](O)=[O:13])([CH3:4])([CH3:3])[CH3:2].S(Cl)([Cl:39])=O>>[C:1]([C:5]1[C:6]([O:35][CH3:36])=[C:7]([CH:24]=[C:25]([N:27]2[CH:32]=[CH:31][C:30](=[O:33])[NH:29][C:28]2=[O:34])[CH:26]=1)/[CH:8]=[CH:9]/[C:10]1[CH:18]=[CH:17][C:16]([NH:19][S:20]([CH3:23])(=[O:22])=[O:21])=[CH:15][C:11]=1[C:12]([Cl:39])=[O:13])([CH3:4])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 24386Thionyl ChlorideHCID 25234654HCID 25234654, compound

Product 1

HCID 86652125HCID 86652125, compound

Procedure

A solution of the product from Example 125 (257 mg, 0.50 mmol) in thionyl chloride (1.5 ml) was heated at 85° C. for 40 min and then concentrated and dried in vacuo to give the title compound as a solid (0.27 g).

Workup

  1. concentrationconcentrated
  2. customdried in vacuo

Sources & evidence

ORD record
ord-b858cb0a55e24238ac263c6675d4c377
Source dataset
uspto-grants-2015_08
Patent number
US09095590B2

Reaction notes

Loading…