Cesium carbonate → HCID 44570902, compound

Participants

Reaction Steps

To a stirred solution of methyl 3-chloro-4-hydroxybenzoate (comm, 6.48 g, 34.73 mmol) in acetonitrile was added cesium carbonate (28.29 g, 86.82 mmol) followed by 4-(bromomethyl)-1,2-difluorobenzene (comm, 10.78 g, 52.09 mmol). The reaction mixture was stirred at room temperature for 18 hours. A sodium hydroxide solution (0.5 M, 210 mL) was then added and the resulting white solid was collected by filtration to yield the title compound, which was used in the next step without further purification.

Provenance & Evidence