反应详情

A solution of 4-hydroxy-2-methoxybenzaldehyde (300 mg, 1.97 mmol) in DMSO (7.5 mL) was added potassium carbonate (545 mg, 3.94 mmol) the resulting suspension was stirred under nitrogen at room temperature for 10 minutes. 4-(Bromomethyl)-1,2-dichlorobenzene was then added (commercial, 473 mg, 1.32 mmol) and the reaction mixture heated to 90° C. for 3 hours. The reaction mixture was cooled to room temperature and partitioned between EtOAc (50 mL) and water (40 mL). The organic layer was washed with water (2×40 mL), dried over magnesium sulphate and evaporated in vacuo to yield the title compound as a solid (530 mg, 86%):

1. temperaturethe reaction mixture heated to 90° C. for 3 hours
2. temperatureThe reaction mixture was cooled to room temperature
3. custompartitioned between EtOAc (50 mL) and water (40 mL)
4. washThe organic layer was washed with water (2×40 mL)
5. dry with materialdried over magnesium sulphate
6. customevaporated in vacuo