反应详情

温度

120 °C

In a 25 ml single-necked round-bottomed flask, to 1.72 ml phosphorous oxide chloride kept at a temperature of 5° C., 0.857 ml quinoline and 3.40 g of 3-bromo-4-methyl-5-nitro-1H-pyridin-2-one are added consecutively. The resulting beige suspension is stirred under heating to 120° C. whereupon a brown solution is obtained. Stirring is continued for 2 hours. Afterwards, the solution is cooled down to an ambient temperature and poured into water. The resulting precipitate is collected by filtration, the filter cake washed with water (4×) and dried to give 3.15 g of the title compound in the form of a brown solid (MP: 60-62° C.).

1. additionare added consecutively
2. customis obtained
3. stirringStirring
4. temperatureAfterwards, the solution is cooled down to an ambient temperature
5. filtrationThe resulting precipitate is collected by filtration
6. washthe filter cake washed with water (4×)
7. customdried