反应详情

NaBH4 (0.27 g, 6.8 mmol) was added to a solution of 2-benzyl-5-methoxy-2,3,3a,8a-tetrahydro-1H-2-aza-cyclopenta[a]inden-8-one (from Example 1, Step C) (1.0 g, 3.4 mmol) in MeOH (17 mL), and stirred for 2 hours at room temperature. The reaction solution was concentrated via rotary evaporation and the residue dissolved in EtOAc. The organic solution was washed with a saturated aqueous NaHCO3 solution and brine, dried over MgSO4, and concentrated. The crude product was obtained without further purification. MS calculated for C19H21NO2+H: 296, observed: 296.

1. concentrationThe reaction solution was concentrated via rotary evaporation
2. dissolutionthe residue dissolved in EtOAc
3. washThe organic solution was washed with a saturated aqueous NaHCO3 solution and brine
4. dry with materialdried over MgSO4
5. concentrationconcentrated