Sulfuric Acid → HCID 86723394, compound

Participants

Reaction Steps

Following the procedure of Example 12, 6-(diethoxymethyl)-3-fluoro-2-(thiazol-2-ylmethyl)-N-tritylpyridin-4-amine (471 mg, 0.85 mmol), conc H2SO4 (0.5 mL), CH3CN (10 mL) and H2O (10 mL) gave the title compound (0.145 g, 71%) as an off-white solid: 1H NMR (400 MHz, CDCl3) δ 9.88 (s, 1H), 7.72 (d, J=3.3 Hz, 1H), 7.28 (d, J=6.7 Hz, 1H), 7.26 (d, J=3.4 Hz, 1H), 4.59 (d, J=2.8 Hz, 2H), 4.56 (br s, 2H); 19F NMR (376 MHz, DMSO-d6) δ −142.44; HRMS-ESI (m/z) [M+H]+ calcd for C10H8FN3OS, 237.0372. found, 237.0363.

Provenance & Evidence